Drosophila melanogasterGenAge entry for Drp1 (Drosophila melanogaster)

Gene information (ID: 2215)

Symbol
Drp1
Name
Dynamin related protein 1
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Short term overexpression of Drp1 in middle-aged female flies increased median lifespan by 21%. Maximum lifespan was also increased. The increase was less pronounced in male flies.
% change in avg or median lifespan
Median lifespan is 21% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as DNM1

    Homologs in other organisms

    Caenorhabditis elegans
    drp-1
    Danio rerio
    si:dkey-32e23.4
    Homo sapiens
    DNM1L
    Mus musculus
    Dnm1l
    Rattus norvegicus
    Dnm1l
    Saccharomyces cerevisiae
    DNM1
    Schizosaccharomyces pombe
    SPBC12C2.08

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (33445)
    Homologues
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    UniProt
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    Internet
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