The rps-15 gene and its possible relation to ageing in roundworms

Gene information (ID: 567)

Symbol: rps-15
Name: Ribosomal Protein, Small subunit
Organism: Caenorhabditis elegans (AnAge)
Known functions and activities: Ribosomal Protein, Small subunit

Potential relevance to longevity and/or ageing

Observations

RNA interference of rps-15 results in an increased lifespan.

% change in avg or median lifespan

Mean lifespan is 9.7% higher.

Lifespan Effect

Increase

Genetic Manipulation

RNA interference

Longevity Category

Anti-Longevity

Primary reference

Observations

RNA interference in young adults reducing mRNA levels approximately two- to fivefold increased median lifespan 10-50% and maximum lifespan by about 40%. A life-extending effect was also observed in daf-16 mutants and sir-2.1 mutants but not in daf-2 mutants. TOR RNA interference further extended lifespan.

% change in max lifespan

Maximum lifespan is about 40% higher.