GenAge entry for SIR4 (Saccharomyces cerevisiae)
Gene information (ID: 608)
- Symbol
- SIR4
- Aliases
- ASD1; STE9; UTH2
- Name
- Silent information regulator
- Organism
- Saccharomyces cerevisiae (AnAge)
- Known functions and activities
- Silencing protein
Potential relevance to longevity and/or ageing
- Observations
- Mutation extends lifespan by more than 30%.
- % change in avg or median lifespan
- Lifespan is more than 30% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Mutation
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- The short life span of a sir4 mutant (20% decrease in mean life span) is due to the simultaneous expression of a and alpha mating-type information, which indirectly causes an increase in rDNA recombination and likely increases the production of extrachromosomal rDNA circles.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Mutation
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- Mean chronological lifespan increased in the a strain
- Lifespan Effect
- Increase
- Genetic Manipulation
- Deletion
- Longevity Category
- Anti-Longevity
- Primary reference
-
Homologs in other organisms
No homologs found
External links
- Saccharomyces Genome Database
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (851813)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar