Saccharomyces cerevisiaeGenAge entry for SIR4 (Saccharomyces cerevisiae)

Gene information (ID: 608)

Symbol
SIR4
Aliases
ASD1; STE9; UTH2
Name
Silent information regulator
Organism
Saccharomyces cerevisiae (AnAge)
Known functions and activities
Silencing protein

Potential relevance to longevity and/or ageing

Observations
Mutation extends lifespan by more than 30%.
% change in avg or median lifespan
Lifespan is more than 30% higher.
Lifespan Effect
Increase
Genetic Manipulation
Mutation
Longevity Category
Anti-Longevity
Primary reference
    Observations
    The short life span of a sir4 mutant (20% decrease in mean life span) is due to the simultaneous expression of a and alpha mating-type information, which indirectly causes an increase in rDNA recombination and likely increases the production of extrachromosomal rDNA circles.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    Mutation
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      Mean chronological lifespan increased in the a strain
      Lifespan Effect
      Increase
      Genetic Manipulation
      Deletion
      Longevity Category
      Anti-Longevity
      Primary reference

        Homologs in other organisms

        No homologs found

        External links

        Saccharomyces Genome Database
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        Ensembl
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        Entrez Gene
        View on Entrez Gene database (851813)
        Homologues
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        UniProt
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        Internet
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