- Symbol
- MET2
- Name
- METhionine requiring
- Organism
- Saccharomyces cerevisiae (AnAge)
- Observations
- Deletion of MET2, which causes cells to be fully impaired in their methionine synthesis and thus strictly dependent on externally supplied methionine, results in both longer maximum and median chronological lifespan. The experiment was performed in synthetic complete medium supplemented with 30 mg/l methionine, and the MET2 strain showed equivalent cell counts and comparable cell cycle arrest with the controls and MET17 strain.
- % change in max lifespan
- Maximum chronological lifespan is approximately 115% higher.
- % change in avg or median lifespan
- Median chronological lifespan is more than 100% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Deletion
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- Mean replicative lifespan decreased in the alpha and a strain
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Deletion
- Longevity Category
- Necessary for fitness
- Primary reference
-
- GenDR gene manipulations
- This gene is present as MET2
- Schizosaccharomyces pombe
- met6
- Saccharomyces Genome Database
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (855444)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for MET2 (Saccharomyces cerevisiae)