Caenorhabditis elegansGenAge entry for unc-51 (Caenorhabditis elegans)

Gene information (ID: 996)

Symbol
unc-51
Name
UNCoordinated
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
10-20% reduction in mean LS
% change in avg or median lifespan
Average lifespan is 10-20% lower.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference
    Observations
    RNAi resulted in a 10%-15% (wild type and daf2 mutants) maximal lifespan extension.
    % change in max lifespan
    Maximum lifespan is 10-15% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    RNA interference
    Longevity Category
    Anti-Longevity
    Primary reference

      In other databases

      GenAge model organism genes
      • A homolog of this gene for Saccharomyces cerevisiae is present as ATG1
      • A homolog of this gene for Drosophila melanogaster is present as Atg1
      GenDR gene manipulations
      • This gene is present as unc-51
      • A homolog of this gene for Saccharomyces cerevisiae is present as ATG1
      LongevityMap
      • A homolog of this gene for Homo sapiens is present as ULK1

      Homologs in other organisms

      Danio rerio
      ulk1b
      Drosophila melanogaster
      Atg1
      Homo sapiens
      ULK1
      Mus musculus
      Ulk1
      Rattus norvegicus
      Ulk1
      Saccharomyces cerevisiae
      ATG1
      Schizosaccharomyces pombe
      atg1

      External links

      WormBase
      Search
      Ensembl
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      Entrez Gene
      View on Entrez Gene database (180311)
      Homologues
      Search HomoloGene
      UniProt
      Search
      Internet
      Search Google or Search Google Scholar