Caenorhabditis elegansGenAge entry for cco-1 (Caenorhabditis elegans)

Gene information (ID: 95)

Symbol
cco-1
Name
Cytochrome C Oxidase
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Electron transport

Potential relevance to longevity and/or ageing

Observations
RNA interference extends lifespan.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference
    Observations
    RNAi resulted in a lifespan extension.
    Lifespan Effect
    Increase
    Genetic Manipulation
    RNA interference
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      RNAi resulted in a 45-61% increase in mean lifespan.
      % change in avg or median lifespan
      Average lifespan is 45-61% higher.
      Lifespan Effect
      Increase
      Genetic Manipulation
      RNA interference
      Longevity Category
      Anti-Longevity
      Primary reference
        Observations
        Extended mean lifespan (30-80% in different backgrounds) when inactivated post developmentally.
        % change in avg or median lifespan
        Average lifespan is 30-80% higher.
        Lifespan Effect
        Increase
        Genetic Manipulation
        RNA interference
        Longevity Category
        Anti-Longevity
        Primary reference
          Observations
          RNAi resulted in a 20% extendned mean lifespan.
          % change in avg or median lifespan
          Average lifespan is 20% higher.
          Lifespan Effect
          Increase
          Genetic Manipulation
          RNA interference
          Longevity Category
          Anti-Longevity
          Primary reference

            In other databases

            GenDR gene manipulations
            • A homolog of this gene for Drosophila melanogaster is present as CoVb

            Homologs in other organisms

            Danio rerio
            cox5b2
            Drosophila melanogaster
            CoVb
            Homo sapiens
            COX5B
            Mus musculus
            Cox5b
            Rattus norvegicus
            uncharacterized_F1LT
            Saccharomyces cerevisiae
            COX4
            Schizosaccharomyces pombe
            cox4

            External links

            WormBase
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            Ensembl
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            Entrez Gene
            View on Entrez Gene database (172832)
            Homologues
            Search HomoloGene
            UniProt
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            Internet
            Search Google or Search Google Scholar