Mus musculusGenAge entry for Cat (Mus musculus)

Gene information (ID: 92)

Symbol
Cat
Aliases
Cas1; Cs-1; Cas-1; 2210418N07
Name
Catalase
Organism
Mus musculus (AnAge)
Known functions and activities
Protects cells from hydrogen peroxide

Potential relevance to longevity and/or ageing

Observations
Overexpression of human catalase targeted to mitochondria extended lifespan by about 20%.
% change in avg or median lifespan
Lifespan is 20% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    The MCAT strain was found to have reduced severity of age-dependent arteriosclerosis and increased genomic stability, as indicated by a decrease in oxidative stress and mitochondrial deletions in heart and muscle tissues. Median and maximum lifespan were increased about 17-21% compared to wild-type controls
    % change in max lifespan
    Maximum lifespan is about 17-21% higher.
    % change in avg or median lifespan
    Median lifespan is about 17-21% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Overexpression in cardiac and skeletal muscles
    Longevity Category
    Pro-Longevity
    Primary reference

      In other databases

      GenAge model organism genes
      • A homolog of this gene for Saccharomyces cerevisiae is present as CTA1
      GenAge human genes
      • A homolog of this gene for Homo sapiens is present as CAT
      LongevityMap
      • A homolog of this gene for Homo sapiens is present as CAT

      Homologs in other organisms

      Caenorhabditis elegans
      ctl-3
      Danio rerio
      cat
      Drosophila melanogaster
      CG9314
      Homo sapiens
      CAT
      Rattus norvegicus
      Cat
      Saccharomyces cerevisiae
      CTA1
      Schizosaccharomyces pombe
      cta1

      External links

      Mouse Genome Informatics
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (12359)
      Homologues
      Search HomoloGene
      UniProt
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      Internet
      Search Google or Search Google Scholar