Drosophila melanogasterGenAge entry for Jafrac1 (Drosophila melanogaster)

Gene information (ID: 856)

Symbol
Jafrac1
Aliases
1633; CG1633; cTPx; Dmel\CG1633; DmTPx-1; dPrx; I; Dpx-47
Name
Thioredoxin peroxidase 1
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Neuronal overexpression of Jafrac1 significantly increased both mean and maximal lifespan, while neuronal knockdown of Jafrac1 , as well as the loss-of-function mutation, caused a reduction in lifespan of up to 30%.
% change in max lifespan
Average male lifespan is 29% higher; Average female lifespan is 26% higher; Maximum male lifespan is up to 26% higher; Maximum female lifespan is aprox. 22% higher.
% change in avg or median lifespan
Average male lifespan is 29% higher; Average female lifespan is 26% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Overexpression caused a 15% mean lifespan extension.
    % change in avg or median lifespan
    Average lifespan is 15% higher
    Lifespan Effect
    Increase
    Genetic Manipulation
    Overexpression
    Longevity Category
    Pro-Longevity
    Primary reference

      In other databases

      GenAge human genes
      • A homolog of this gene for Homo sapiens is present as PRDX1

      Homologs in other organisms

      Danio rerio
      prdx1
      Homo sapiens
      PRDX1
      Rattus norvegicus
      Prdx1
      Schizosaccharomyces pombe
      tpx1

      External links

      FlyBase
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (53578)
      Homologues
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      UniProt
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      Internet
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