Drosophila melanogasterGenAge entry for E(z) (Drosophila melanogaster)

Gene information (ID: 844)

Symbol
E(z)
Aliases
CG6502; Dmel\CG6502; E(Z); E(z)1; Ez; EZ; E[z]; l(3)1902;
Name
Enhancer of zeste
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Flies heterozygous for the protein null E(z)63 or the catalytically inactive E(z)731 mutation that were progeny of an out-cross to an Oregon-R (O-R) wild-type strain exhibited a substantially greater median life span than the O-R control (71% and 76%, respectively). When derived from an out-cross to a longer-lived Canton-S (C-S) wild-type strain, the median life span of E(z)63 heterozygotes was 33% longer than the C-S control
% change in max lifespan
Maximum lifespan is approximately 54% higher.
% change in avg or median lifespan
Median lifespan is 76% higher.
Lifespan Effect
Increase
Genetic Manipulation
Mutations
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as mes-2

    Homologs in other organisms

    Caenorhabditis elegans
    mes-2
    Danio rerio
    ezh1
    Homo sapiens
    EZH1
    Mus musculus
    Ezh1
    Rattus norvegicus
    Ezh1

    External links

    FlyBase
    Search
    Ensembl
    Search
    Entrez Gene
    View on Entrez Gene database (39203)
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar