Mus musculusGenAge entry for Sirt7 (Mus musculus)

Gene information (ID: 824)

Symbol
Sirt7
Name
Sirtuin 7 (silent mating type information regulation 2, homolog) 7 (S. cerevisiae)
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
No obvious phenotype was observed in heterozygous mutant Sirt7 animals, whereas homozygous mutants showed various signs of aging-related changes and died prematurely. Mutant mice developed kyphosis and lost subcutaneous fat early in life, and showed a general decrease in stress-resistance mechanisms. Mice develop heart hypertrophy and inflammatory cardiomyopathy. Sirt7 mutant hearts are also characterized by extensive fibrosis, leading to an increase in collagen III accumulation.
% change in max lifespan
Maximum lifespan is 55% lower.
% change in avg or median lifespan
Average lifespan is 59% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Mutations
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as SIRT7

    Homologs in other organisms

    Danio rerio
    sirt7
    Homo sapiens
    SIRT7
    Rattus norvegicus
    Sirt7

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (209011)
    Homologues
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    UniProt
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    Internet
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