Mus musculusGenAge entry for Jund (Mus musculus)

Gene information (ID: 821)

Symbol
Jund
Aliases
Jund1
Name
Jun proto-oncogene related gene d
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
junD -/- mice exhibit features of premature aging (cataracts, slight hair loss, graying, varying degrees of cachexia, and lordokyphosis), and shortened lifespan. They also display persistent hypoglycemia due to enhanced insulin secretion. Mice also developed various types of neoplasia (most frequent cause of death being high-grade diffuse lymphomas) at similar frequency as in old WT mice.
% change in max lifespan
Maximum lifespan is 14% lower.
% change in avg or median lifespan
Average lifespan is 17% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Knockout
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as JUND

    Homologs in other organisms

    Danio rerio
    jund
    Homo sapiens
    JUND
    Rattus norvegicus
    Jund

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (16478)
    Homologues
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    UniProt
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    Internet
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