Mus musculusGenAge entry for Eps8 (Mus musculus)

Gene information (ID: 817)

Symbol
Eps8
Aliases
AW261790
Name
Epidermal growth factor receptor pathway substrate 8
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Eps8 KO mice show a lean phenotype and increased lifespan. Mice appear to be caloric restricted, most probably due to an impaired fat absorption. Median survival of Eps8 KO mice was increased by 26%, mean survival by 37% and maximum survival by 9%. Lifespan was significantly extended both in male and female Eps8 KO mice.
% change in max lifespan
Maximum lifespan is 9% higher.
% change in avg or median lifespan
Median lifespan is 26% higher; Average lifespan is 37% higher.
Lifespan Effect
Increase
Genetic Manipulation
Deletion
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as EPS8

    Homologs in other organisms

    Danio rerio
    zgc:56041
    Homo sapiens
    EPS8
    Rattus norvegicus
    Eps8

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (13860)
    Homologues
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    UniProt
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    Internet
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