Mus musculusGenAge entry for Eef1e1 (Mus musculus)

Gene information (ID: 816)

Symbol
Eef1e1
Aliases
1110003A02Rik
Name
Eukaryotic translation elongation factor 1 epsilon 1
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Mice that are homozygous null for AIMP3 showed early embryonic death; heterozygous mice are born alive but show highly increased susceptibility to various cancers. Transgenic mice that express AIMP3 constitutively at higher level than WT controls exhibited a significantly shorter mean lifespan and a phenotype characteristic to mouse progeroid models (mice stopped gaining weight much earlier than their WT littermates, displayed alopecia, wrinkled skin with reduced adipocytes, lordokyphosis, reduced bone mineral deposits in female, and reduced bone thickness).
% change in avg or median lifespan
Median lifespan is 50% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Overexpression
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as EEF1E1

    Homologs in other organisms

    Danio rerio
    wu:fe14c11
    Drosophila melanogaster
    CG30185;Gr59f
    Homo sapiens
    EEF1E1
    Rattus norvegicus
    Eef1e1

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (66143)
    Homologues
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    UniProt
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    Internet
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