Mus musculusGenAge entry for Dmd (Mus musculus)

Gene information (ID: 815)

Symbol
Dmd
Aliases
dys; mdx; pke; Dp71; Dp427; DXSmh7; DXSmh9
Name
Dystrophin, muscular dystrophy
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Reduction in lifespan and displayed a progressively dystrophic muscle histopathology. Old mdx mice were also prone to develop muscle tumors that resembled the human form of alveolar rhabdomyosarcoma.
% change in max lifespan
Maximum lifespan is 22% lower.
% change in avg or median lifespan
Average female lifespan is 17% lower; Average male lifespan is 19% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Mutations
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Drosophila melanogaster is present as Dys

    Homologs in other organisms

    Danio rerio
    dmd
    Drosophila melanogaster
    Dys
    Homo sapiens
    DMD
    Rattus norvegicus
    uncharacterized_F1M7

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (13405)
    Homologues
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    UniProt
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    Internet
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