Mus musculusGenAge entry for Cisd2 (Mus musculus)

Gene information (ID: 813)

Symbol
Cisd2
Aliases
Zcd2; Miner1; Noxp70; AI848398; 1500009M05Rik; 1500026J
Name
CDGSH iron sulfur domain 2
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Knockout mice have a shorten lifespan and exhibit signs of premature aging, including prominent eyes and protruding ears, ocular abnormalities (opaque eyes and blindness), early depigmentation of the fur, hair follicle atrophy, decreased hair density and regrowth rate, thickened dermis, significant decrease in subcutaneous adipose tissue and muscle, muscle atrophy, osteroporosis, decrease in pulmonary capacity.
% change in max lifespan
Maximum lifespan is 15% lower.
% change in avg or median lifespan
Median lifespan is 38.5% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Knockout
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Lifespan was extended for both sexes of the Cisd2 TG mice (gain-of-function mutation) without any statistically significant sex difference. In addition, when the Cisd2 TG mice were compared to WT mice, there was no obvious phenotypic effect on body weight or body temperature, or on the measured metabolic indices, including intake of food and water and generation of urine and stool. Aging appeared to be delayed in skin (measured by hair greying and mice's capacity to repel water), muscle and neurons. Mouse mutants also displayed protection of mitochondria from age-associated damage, and reduction of the age-associated decline in mitochondrial function and whole-body energy metabolism.
    % change in max lifespan
    Maximum male lifespan is 11.7% higher; Maximum female lifespan is 29.6% higher.
    % change in avg or median lifespan
    Median male lifespan is 19.4% lower; Median female lifespan is 18.8% lower.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Overexpression
    Longevity Category
    Pro-Longevity
    Primary reference

      In other databases

      GenAge human genes
      • A homolog of this gene for Homo sapiens is present as CISD2

      Homologs in other organisms

      Caenorhabditis elegans
      CELE_W02B12.15
      Danio rerio
      cisd2
      Drosophila melanogaster
      CG1458
      Homo sapiens
      CISD2
      Rattus norvegicus
      Cisd2

      External links

      Mouse Genome Informatics
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (67006)
      Homologues
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      UniProt
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      Internet
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