Caenorhabditis elegansGenAge entry for age-1 (Caenorhabditis elegans)

Gene information (ID: 7)

Symbol
age-1
Name
AGEing alteration AGE-1, abnormal DAuer Formation DAF-23
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Phosphoinositide-3-kinase

Potential relevance to longevity and/or ageing

Observations
65 % increase in mean lifespan and a 110 % increase in maximum lifespan at 25 degrees. age-1 mutant hermaphrodites show a 50% slower rate of mortality acceleration than wild-type.
% change in max lifespan
Maximum lifespan is 110% higher.
% change in avg or median lifespan
Average lifespan is 65% higher.
Lifespan Effect
Increase
Genetic Manipulation
Mutation
Longevity Category
Anti-Longevity
Primary reference
    Observations
    Mutants presented a double adult lifespan.
    % change in avg or median lifespan
    Lifespan is two-fold higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Mutation
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      Knockout mutants have a 40-65% increase in mean lifespan and a 65-110% increase in maximum lifespan.
      % change in max lifespan
      Maximum lifespan is 65-110% higher.
      % change in avg or median lifespan
      Average lifespan is 40-65% higher.
      Lifespan Effect
      Increase
      Genetic Manipulation
      Knockout
      Longevity Category
      Anti-Longevity
      Primary reference
        Observations
        170% mean lifespan extension
        % change in avg or median lifespan
        Average lifespan is 170% higher.
        Lifespan Effect
        Increase
        Genetic Manipulation
        RNA interference
        Longevity Category
        Anti-Longevity
        Primary reference
          Observations
          C. elegans strains bearing homozygous nonsense mutations in the age-1 gene, which encodes the class-I phosphatidylinositol 3-kinase catalytic subunit (PI3KCS), produce progeny that were thought to undergo obligatory developmental arrest. After prolonged developmental times at 15 - 20 C, they mature into extremely long-lived adults with near-normal feeding rates and motility. They survive to a median of 145-190 days at 20 C, with nearly 10-fold extension of both median and maximum adult lifespan relative to N2DRM, a long-lived wild-type stock into which the null mutant was outcrossed. PI3K-null adults, although a little less thermotolerant, are considerably more resistant to oxidative and electrophilic stresses than worms bearing normal or less long-lived alleles. Their unprecedented factorial gains in survival, under both normal and toxic environments, are attributed to elimination of residual and maternally-contributed PI3KCS or its products, and consequent modification of kinase signaling cascades.
          % change in max lifespan
          Maximum lifespan is nearly 10-fold greater.
          % change in avg or median lifespan
          Average lifespan is nearly 10-fold greater.
          Lifespan Effect
          Increase
          Genetic Manipulation
          Mutation
          Longevity Category
          Anti-Longevity
          Primary reference

            In other databases

            GenAge model organism genes
            • A homolog of this gene for Drosophila melanogaster is present as Pi3K92E
            GenDR gene manipulations
            • This gene is present as age-1
            LongevityMap
            • A homolog of this gene for Homo sapiens is present as PIK3CG

            Homologs in other organisms

            Danio rerio
            pik3cg
            Drosophila melanogaster
            Pi3K92E
            Homo sapiens
            PIK3CG
            Mus musculus
            Pik3cg
            Rattus norvegicus
            Pik3cd

            External links

            WormBase
            Search
            Ensembl
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            Entrez Gene
            View on Entrez Gene database (174762)
            Homologues
            Search HomoloGene
            UniProt
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            Internet
            Search Google or Search Google Scholar