Mus musculusGenAge entry for Ucp2 (Mus musculus)

Gene information (ID: 696)

Symbol
Ucp2
Aliases
Slc25a8
Name
uncoupling protein 2 (mitochondrial, proton carrier)
Organism
Mus musculus (AnAge)
Known functions and activities
Mitochondrial uncoupling proteins create proton leaks across the inner mitochondrial membrane to uncouple oxidative phosphorylation from ATP synthesis

Potential relevance to longevity and/or ageing

Observations
Overexpression in hypocretin neurons results in mice with elevated hypothalamic temperature and reduction of core body temperature and a 12% increase in median lifespan in males and 20% increase in females.
% change in avg or median lifespan
Median male lifespan is 12% higher; Median female lifespan is 20% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Drosophila melanogaster is present as UCP2
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as UCP2
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as UCP2

    Homologs in other organisms

    Danio rerio
    ucp2
    Homo sapiens
    UCP2
    Rattus norvegicus
    Ucp2

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (22228)
    Homologues
    Search HomoloGene
    UniProt
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    Internet
    Search Google or Search Google Scholar