Caenorhabditis elegansGenAge entry for top-1 (Caenorhabditis elegans)

Gene information (ID: 676)

Symbol
top-1
Name
TOPoisomerase
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
DNA topoisomerase I

Potential relevance to longevity and/or ageing

Observations
RNA interference decreased median lifespan by 19% in wild type animals and 42% in daf-2 mutants.
% change in avg or median lifespan
Median lifespan is 19% lower.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as TOP1

    Homologs in other organisms

    Danio rerio
    top1
    Drosophila melanogaster
    Top1
    Homo sapiens
    TOP1MT
    Mus musculus
    Top1
    Rattus norvegicus
    Top1
    Saccharomyces cerevisiae
    TOP1
    Schizosaccharomyces pombe
    top1

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (266847)
    Homologues
    Search HomoloGene
    UniProt
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    Internet
    Search Google or Search Google Scholar