Drosophila melanogasterGenAge entry for Sod (Drosophila melanogaster)

Gene information (ID: 622)

Symbol
Sod
Aliases
CG11793; cSod; cSOD; Cu; Cu-Zn; SOD; Cu/Zn; sod; Cu/Zn; SOD
Name
Superoxide dismutase
Organism
Drosophila melanogaster (AnAge)
Known functions and activities
Antioxidant

Potential relevance to longevity and/or ageing

Observations
Mutant flies displayed infertility and a reduction in lifespan.
Lifespan Effect
Decrease
Genetic Manipulation
Mutation
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Overexpression of catalase and Sod1 resulted in a one-third lifespan extension, a slower rate of mortality acceleration, and a delayed loss in physical performance.
    % change in avg or median lifespan
    Average lifespan is one-third higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Overexpression
    Longevity Category
    Pro-Longevity
    Primary reference
      Observations
      Cu/ZnSOD overexpression extended the mean lifespan by up to 48%. Simultaneous overexpression of catalase with Cu/ZnSOD had no added benefit, presumably due to a preexisting excess of catalase.
      % change in avg or median lifespan
      Average lifespan is up to 48% higher.
      Lifespan Effect
      Increase
      Genetic Manipulation
      Overexpression
      Longevity Category
      Pro-Longevity
      Primary reference

        In other databases

        GenAge model organism genes
        • A homolog of this gene for Saccharomyces cerevisiae is present as SOD1
        GenAge human genes
        • A homolog of this gene for Homo sapiens is present as SOD1
        GenDR gene manipulations
        • A homolog of this gene for Saccharomyces cerevisiae is present as SOD1
        LongevityMap
        • A homolog of this gene for Homo sapiens is present as SOD1
        CellAge
        • A homolog of this gene for Homo sapiens is present as SOD1

        Homologs in other organisms

        Caenorhabditis elegans
        sod-5
        Danio rerio
        sod1
        Homo sapiens
        SOD1
        Mus musculus
        Sod1
        Rattus norvegicus
        Sod1
        Saccharomyces cerevisiae
        SOD1
        Schizosaccharomyces pombe
        sod1

        External links

        FlyBase
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        Ensembl
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        Entrez Gene
        View on Entrez Gene database (39251)
        Homologues
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        UniProt
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        Internet
        Search Google or Search Google Scholar