Saccharomyces cerevisiaeGenAge entry for SOD1 (Saccharomyces cerevisiae)

Gene information (ID: 621)

Symbol
SOD1
Aliases
CRS4
Name
Cu, Zn superoxide dismutase
Organism
Saccharomyces cerevisiae (AnAge)
Known functions and activities
Protects cells against oxygen toxicity

Potential relevance to longevity and/or ageing

Observations
Overexpression of Sod1 and Sod2 extends survival by 30%.
% change in avg or median lifespan
Lifespan is 30% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Increasing the level of active Cu, Zn-Sod in yeast was found to require either growth in the presence of high copper, or the simultaneous overexpression of both SOD1 and CCS1 (the latter being the gene that encodes the chaperone dedicated to Cu(2+)-loading of Sod1p in vivo). Dual SOD1 + CCS1 overexpression elevated the levels of Cu,Zn-Sod activity six- to eight-fold in vegetative cultures. It also increased the optimized survival of stationary cells up to two-fold, showing this chronological lifespan is ultimately limited by oxidative stress. In contrast, several detrimental effects resulted when the SOD1 gene was overexpressed in the absence of either high copper or a simultaneous overexpression of CCS1. Both the chronological and the replicative lifespans were shortened; the cells displayed an abnormally high level of endogenous oxidative stress, resulting in a high rate of spontaneous mutation. Such harmful effects were all reversed through the overexpression of CCS1.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Overexpression
    Longevity Category
    Pro-Longevity
    Primary reference
      Observations
      40% decrease in replicative lifespan
      % change in avg or median lifespan
      Replicative lifespan is 40% lower.
      Lifespan Effect
      Decrease
      Genetic Manipulation
      Deletion
      Longevity Category
      Necessary for fitness
      Primary reference

        In other databases

        GenAge model organism genes
        • A homolog of this gene for Drosophila melanogaster is present as Sod
        GenAge human genes
        • A homolog of this gene for Homo sapiens is present as SOD1
        GenDR gene manipulations
        • This gene is present as SOD1
        LongevityMap
        • A homolog of this gene for Homo sapiens is present as SOD1
        CellAge
        • A homolog of this gene for Homo sapiens is present as SOD1

        Homologs in other organisms

        Caenorhabditis elegans
        sod-5
        Danio rerio
        sod1
        Drosophila melanogaster
        Sod
        Homo sapiens
        SOD1
        Mus musculus
        Sod1
        Rattus norvegicus
        Sod1
        Schizosaccharomyces pombe
        sod1

        External links

        Saccharomyces Genome Database
        Search
        Ensembl
        Search
        Entrez Gene
        View on Entrez Gene database (853568)
        Homologues
        Search HomoloGene
        UniProt
        Search
        Internet
        Search Google or Search Google Scholar