Mus musculusGenAge entry for Shc1 (Mus musculus)

Gene information (ID: 601)

Symbol
Shc1
Aliases
Shc; p66; ShcA; p66shc
Name
SHC (Src homology 2 domain containing) transforming protein 1
Organism
Mus musculus (AnAge)
Known functions and activities
Regulation of intra-cellular redox levels, signal transduction, and apoptosis

Potential relevance to longevity and/or ageing

Observations
In contrast to a previous study (Migliaccio et al., 1999), knockout of Shc1 was not found to increase median or maximum life span in mice.
Lifespan Effect
No Change
Genetic Manipulation
Knockout
Primary reference
    Observations
    Knockout mice had a 30% increase in lifespan.
    % change in avg or median lifespan
    Lifespan is 30% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Knockout
    Longevity Category
    Anti-Longevity
    Primary reference

      In other databases

      GenAge human genes
      • A homolog of this gene for Homo sapiens is present as SHC1
      LongevityMap
      • A homolog of this gene for Homo sapiens is present as SHC1

      Homologs in other organisms

      Danio rerio
      si:dkey-246i14.4
      Homo sapiens
      SHC1
      Rattus norvegicus
      Shc1

      External links

      Mouse Genome Informatics
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (20416)
      Homologues
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      UniProt
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      Internet
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