Mus musculusGenAge entry for Adcy5 (Mus musculus)

Gene information (ID: 6)

Symbol
Adcy5
Aliases
Ac5; AW121902
Name
adenylate cyclase 5
Organism
Mus musculus (AnAge)
Known functions and activities
Synthesis of cAMP

Potential relevance to longevity and/or ageing

Observations
Knock out mice are resistant to cardiac stress, have an increased median lifespan of 30% and an increased maximal lifespan of 12%. They are also protected from age-related reduced bone density and susceptibility to fractures, and reduced cardiac function.
% change in max lifespan
Maximum lifespan is 12% higher.
% change in avg or median lifespan
Median lifespan is 30% higher.
Lifespan Effect
Increase
Genetic Manipulation
Knockout
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as ADCY5
    GenDR gene manipulations
    • This gene is present as Adcy5
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as ADCY5

    Homologs in other organisms

    Danio rerio
    adcy5
    Homo sapiens
    ADCY5
    Rattus norvegicus
    Adcy5

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (224129)
    Homologues
    Search HomoloGene
    UniProt
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    Internet
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