Caenorhabditis elegansGenAge entry for rsks-1 (Caenorhabditis elegans)

Gene information (ID: 578)

Symbol
rsks-1
Name
RSK-pSeventy (RSK-p70 kinase) homolog
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Translational regulator

Potential relevance to longevity and/or ageing

Observations
RNA interference reducing S6K (rsks-1) mRNA levels by about two-fold extended mean lifespan 13-47% and maximum lifespan by up to 60%. Deletion mutants also lived longer. A life-extending effect was also observed in daf-16 mutants and sir-2.1 mutants but not in daf-2 mutants. TOR RNA interference further extended lifespan.
% change in max lifespan
Maximum lifespan is up to 60% higher.
% change in avg or median lifespan
Average lifespan is 13-47% higher.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference
    Observations
    RNAi resulted in a 22% maximum lifespan increase. In the rsks-1 (ok1255) mutant background, inhibition of ifg-1 led to a further extension of 40% in maximum lifespan. However, inhibition of let-363 (worm homologue of TOR) by RNAi in rsks-1 mutant background led to a slight shortening of MLS. In the daf-2 (e1370) mutant background, inhibition of either ifg-1 or rsks-1 further extended lifespan by 70% and 24%, respectively. Inhibition of either ifg-1 or rsks-1 extended lifespan by 27% and 14%, respectively, in a daf-16 (mu86 ) background. Inhibition of either ifg-1 or rsks-1 in the clk-1(e2519) mutant background led to a further lifespan extension by 19% and 13%, respectively. Inhibition of either ifg-1 or rsks-1 extended lifespan in the eat-2 background by 54% and 11%, respectively. In a sir-2.1 mutant background, ifg-1 inhibition extended lifespan by 93% and rsks-1 inhibition by 33%.
    % change in max lifespan
    Maximum lifespan is 22% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    RNA interference
    Longevity Category
    Anti-Longevity
    Primary reference

      In other databases

      GenAge model organism genes
      • A homolog of this gene for Drosophila melanogaster is present as S6k

      Homologs in other organisms

      Danio rerio
      rps6kb1a
      Drosophila melanogaster
      S6k
      Homo sapiens
      RPS6KB2
      Mus musculus
      Rps6kb2
      Rattus norvegicus
      Rps6kb2

      External links

      WormBase
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (176554)
      Homologues
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      UniProt
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      Internet
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