Mus musculusGenAge entry for Bub3 (Mus musculus)

Gene information (ID: 51)

Symbol
Bub3
Aliases
C78067; AU019800; AU021329; AU043350; AW146323
Name
budding uninhibited by benzimidazoles 3 homolog (S. cerevisiae)
Organism
Mus musculus (AnAge)
Known functions and activities
Kinase involved in the spindle checkpoint function

Potential relevance to longevity and/or ageing

Observations
Haploinsufficiency of Bub3 and Rae1, but not haploinsufficiency of either gene by itself, reduces lifespan by 12% and appears to accelerate ageing.
% change in avg or median lifespan
Lifespan is 12% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Mutation
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as bub-3
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as BUB3

    Homologs in other organisms

    Caenorhabditis elegans
    bub-3
    Danio rerio
    bub3
    Drosophila melanogaster
    Bub3
    Homo sapiens
    BUB3
    Schizosaccharomyces pombe
    bub3

    External links

    Mouse Genome Informatics
    Search
    Ensembl
    Search
    Entrez Gene
    View on Entrez Gene database (12237)
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar