Mus musculusGenAge entry for Bub1b (Mus musculus)

Gene information (ID: 50)

Symbol
Bub1b
Aliases
BUBR1; AU045529
Name
budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)
Organism
Mus musculus (AnAge)
Known functions and activities
Kinase involved in the spindle checkpoint function

Potential relevance to longevity and/or ageing

Observations
Overexpression of BubR1 preserves genomic integrity, reduces tumorigenesis and extends average and maximum lifespan.
% change in max lifespan
Maximum lifespan is 18% higher.
% change in avg or median lifespan
Average lifespan is 14% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Knockout mutant mice exhibit symptoms of accelerated ageing such as short lifespan, lordokyphosis, and fat loss.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    Knockout
    Longevity Category
    Pro-Longevity
    Primary reference

      In other databases

      GenAge human genes
      • A homolog of this gene for Homo sapiens is present as BUB1B

      Homologs in other organisms

      Homo sapiens
      BUB1B
      Rattus norvegicus
      Bub1b

      External links

      Mouse Genome Informatics
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (12236)
      Homologues
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      UniProt
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      Internet
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