Drosophila melanogasterGenAge entry for Pcmt (Drosophila melanogaster)

Gene information (ID: 498)

Symbol
Pcmt
Aliases
CG2152; Dmel\CG2152; dPIMT; pcmt; Pimt; PIMT
Name
Protein-L-isoaspartate (D-aspartate) O-methyltransferase
Organism
Drosophila melanogaster (AnAge)
Known functions and activities
Protein repair

Potential relevance to longevity and/or ageing

Observations
Overexpression extended lifespan by 32-39% at 29 degrees but not at 25 degrees.
% change in avg or median lifespan
Lifespan is 32-39% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Adult lifespan of flies with overexpressed pcmt was extended.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Overexpression
    Longevity Category
    Pro-Longevity
    Primary reference

      In other databases

      GenAge model organism genes
      • A homolog of this gene for Caenorhabditis elegans is present as pcm-1
      GenAge human genes
      • A homolog of this gene for Homo sapiens is present as PCMT1

      Homologs in other organisms

      Caenorhabditis elegans
      pcm-1
      Danio rerio
      pcmtl
      Homo sapiens
      PCMT1
      Mus musculus
      Pcmt1
      Rattus norvegicus
      Pcmt1
      Schizosaccharomyces pombe
      pcm2

      External links

      FlyBase
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (40668)
      Homologues
      Search HomoloGene
      UniProt
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      Internet
      Search Google or Search Google Scholar