Caenorhabditis elegansGenAge entry for par-5 (Caenorhabditis elegans)

Gene information (ID: 493)

Symbol
par-5
Name
abnormal embryonic PARtitioning of cytoplasm
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
RNA interference slightly shortens lifespan and suppresses life-extension by sir-2.1 overexpression but not by daf-2 mutants. Overexpression extends lifespan by 30%, but is suppressed by RNA interference of daf-16.
% change in avg or median lifespan
Lifespan is 30% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Post developmental RNAi let to a 15% mean lifespan reduction in wild type though no significant changes in maximal lifespan.
    % change in avg or median lifespan
    Average lifespan is 15% lower.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    RNA interference
    Longevity Category
    Pro-Longevity
    Primary reference

      In other databases

      GenAge model organism genes
      • A homolog of this gene for Saccharomyces cerevisiae is present as BMH1

      Homologs in other organisms

      Danio rerio
      ywhaqa
      Drosophila melanogaster
      14-3-3zeta
      Homo sapiens
      YWHAB
      Mus musculus
      Ywhaq
      Rattus norvegicus
      Ywhaq
      Saccharomyces cerevisiae
      BMH1
      Schizosaccharomyces pombe
      rad25

      External links

      WormBase
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (178113)
      Homologues
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      UniProt
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      Internet
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