Mus musculusGenAge entry for Pappa (Mus musculus)

Gene information (ID: 492)

Symbol
Pappa
Aliases
PAG1; PAPP-A; IGFBP-4ase; 8430414N03Rik
Name
Pregnancy-associated plasma protein A
Organism
Mus musculus (AnAge)
Known functions and activities
Could be involved in local cell proliferative processes

Potential relevance to longevity and/or ageing

Observations
Genetic deletion of PAPPA extended mean and maximum lifespan by 30-40% and reduced cancer incidence with no reduction in food intake or secondary endocrine abnormalities.
% change in max lifespan
Maximum lifespan is 30-40% higher.
Lifespan Effect
Increase
Genetic Manipulation
Deletion
Longevity Category
Anti-Longevity
Primary reference
    Observations
    Knockout mice had an approximately 30% increase in lifespan.
    % change in avg or median lifespan
    Average lifespan is 30% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Knockout
    Longevity Category
    Anti-Longevity
    Primary reference

      In other databases

      GenAge human genes
      • A homolog of this gene for Homo sapiens is present as PAPPA

      Homologs in other organisms

      Danio rerio
      CABZ01089223.1
      Homo sapiens
      PAPPA
      Rattus norvegicus
      Pappa

      External links

      Mouse Genome Informatics
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (18491)
      Homologues
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      UniProt
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      Internet
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