Drosophila melanogasterGenAge entry for Eip71CD (Drosophila melanogaster)

Gene information (ID: 445)

Symbol
Eip71CD
Aliases
CG7266; Dmel\CG7266; dmsrA; DROZ60MEX; Eip28; Eip28; /29
Name
Ecdysone-induced protein 28/29kD
Organism
Drosophila melanogaster (AnAge)
Known functions and activities
MSRA repairs damage resulting from oxidative stress

Potential relevance to longevity and/or ageing

Observations
Overexpression in the nervous system extended lifespan by up to 70%, increased resistance to oxidative stress, and delayed the onset of senescence-induced decline in activity levels and reproductive capacity.
% change in avg or median lifespan
Lifespan is up to 70% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Mean and maximal lifepsan was increased by up to 20% in flies with overexpressed Msra.
    % change in max lifespan
    Maximum lifespan is up to 20% higher.
    % change in avg or median lifespan
    Average lifespan is up to 20% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Overexpression
    Longevity Category
    Pro-Longevity
    Primary reference

      In other databases

      GenAge model organism genes
      • A homolog of this gene for Mus musculus is present as Msra
      • A homolog of this gene for Saccharomyces cerevisiae is present as MXR1
      GenAge human genes
      • A homolog of this gene for Homo sapiens is present as MSRA

      Homologs in other organisms

      Caenorhabditis elegans
      msra-1
      Danio rerio
      im:7149628
      Homo sapiens
      MSRA
      Mus musculus
      Msra
      Rattus norvegicus
      Msra
      Saccharomyces cerevisiae
      MXR1
      Schizosaccharomyces pombe
      mxr1

      External links

      FlyBase
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (39675)
      Homologues
      Search HomoloGene
      UniProt
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      Internet
      Search Google or Search Google Scholar