Caenorhabditis elegansGenAge entry for mcm-2 (Caenorhabditis elegans)

Gene information (ID: 426)

Symbol
mcm-2
Name
yeast MCM (licensing factor) related
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Chromatin modificatioon

Potential relevance to longevity and/or ageing

Observations
RNA interference in adulthood resulted in a 15% mean lifespan extension.
% change in avg or median lifespan
Average lifespan is 15% higher.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference
    Observations
    RNAi let to a 33% decrease in median lifespan in daf-2 background and a 14% decrease in lifespan in a wild-type background.
    % change in avg or median lifespan
    Median lifespan is 14% lower.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    RNA interference
    Longevity Category
    Pro-Longevity
    Primary reference

      In other databases

      GenAge model organism genes
      • A homolog of this gene for Mus musculus is present as Mcm2

      Homologs in other organisms

      Danio rerio
      mcm2
      Drosophila melanogaster
      Mcm2
      Homo sapiens
      MCM2
      Mus musculus
      Mcm2
      Rattus norvegicus
      Mcm2
      Saccharomyces cerevisiae
      MCM2
      Schizosaccharomyces pombe
      mcm2

      External links

      WormBase
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (174841)
      Homologues
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      UniProt
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      Internet
      Search Google or Search Google Scholar