Mus musculusGenAge entry for Lmna (Mus musculus)

Gene information (ID: 415)

Symbol
Lmna
Aliases
Dhe
Name
lamin A
Organism
Mus musculus (AnAge)
Known functions and activities
LMNA encodes components of the lamina

Potential relevance to longevity and/or ageing

Observations
The Lmna "progeria" allele (G690G), obtained through a mutation responsible for an increased ratio of Progerin/Lamin A, results in shorter mice lifespan compared to wild-type. For the heterozygous mice, median lifespan is reduced by ~40%, while the homozygous mice live about 83% lower.
% change in avg or median lifespan
Median lifespan is up to 83% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Mutation
Longevity Category
Pro-Longevity
Primary reference
    Observations
    The Lmna LCS, a knock-in mutation responsible for specifically not-producing Progerin, results in an increased lifespan. For the heterozygous mutation, median lifespan is extended by ~13%, while for the homozygous mutation median lifespan is ~10% longer.
    % change in avg or median lifespan
    Median lifespan is up to 13% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Mutation
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      Homozygous mice display signs of premature ageing, including a marked reduction in growth rate and death by 4 weeks of age.
      Lifespan Effect
      Decrease
      Genetic Manipulation
      Knockout
      Longevity Category
      Pro-Longevity
      Primary reference

        In other databases

        GenAge model organism genes
        • A homolog of this gene for Caenorhabditis elegans is present as lmn-1
        GenAge human genes
        • A homolog of this gene for Homo sapiens is present as LMNA
        LongevityMap
        • A homolog of this gene for Homo sapiens is present as LMNA

        Homologs in other organisms

        Caenorhabditis elegans
        lmn-1
        Danio rerio
        lmna
        Drosophila melanogaster
        LamC
        Homo sapiens
        LMNA
        Rattus norvegicus
        Lmna

        External links

        Mouse Genome Informatics
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        Ensembl
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        Entrez Gene
        View on Entrez Gene database (16905)
        Homologues
        Search HomoloGene
        UniProt
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        Internet
        Search Google or Search Google Scholar