Caenorhabditis elegansGenAge entry for dld-1 (Caenorhabditis elegans)

Gene information (ID: 413)

Symbol
dld-1
Name
Protein DLD-1
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Dihydrolipoamide dehydrogenase

Potential relevance to longevity and/or ageing

Observations
Intermediate doses of DLD RNAi (RNAi dilutions of 1/20 and 1/50) significantly (P < 0.005) shortened adult lifespan by 20-25%, whereas more potent doses of DLD RNAi (non diluted) significantly (P < 0.005) extended adult lifespan by 10%.
Lifespan Effect
Not Recorded
Genetic Manipulation
RNA interference
Longevity Category
Not Recorded
Primary reference
    Observations
    RNA interference increased mean lifespan by 61%.
    % change in avg or median lifespan
    Average lifespan is 61% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    RNA interference
    Longevity Category
    Anti-Longevity
    Primary reference

      In other databases

      GenAge model organism genes
      • A homolog of this gene for Saccharomyces cerevisiae is present as LPD1
      LongevityMap
      • A homolog of this gene for Homo sapiens is present as DLD

      Homologs in other organisms

      Danio rerio
      dldh
      Drosophila melanogaster
      CG7430
      Homo sapiens
      DLD
      Mus musculus
      Dld
      Rattus norvegicus
      uncharacterized_M0R6
      Saccharomyces cerevisiae
      LPD1
      Schizosaccharomyces pombe
      dld1

      External links

      WormBase
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (178387)
      Homologues
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      UniProt
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      Internet
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