Saccharomyces cerevisiaeGenAge entry for LAT1 (Saccharomyces cerevisiae)

Gene information (ID: 400)

Symbol
LAT1
Aliases
ODP2; PDA2
Name
Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes
Organism
Saccharomyces cerevisiae (AnAge)
Known functions and activities
Dihydrolipoamide acetyltransferase

Potential relevance to longevity and/or ageing

Observations
Deletion abolished the lifespan extension conferred by calorie restriction. Overexpression extended mean lifespan by 20%, did not further extend lifespan under CR, and was not dependent on the Sir2 family. Overexpression also extended cell survival during prolonged culture at stationary phase.
% change in avg or median lifespan
Average lifespan is 20% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as dlat-1
    GenDR gene manipulations
    • This gene is present as LAT1

    Homologs in other organisms

    Caenorhabditis elegans
    F23B12.5
    Danio rerio
    dlat
    Drosophila melanogaster
    CG5261
    Homo sapiens
    DLAT
    Mus musculus
    Dlat
    Rattus norvegicus
    uncharacterized_M0RA
    Schizosaccharomyces pombe
    lat1

    External links

    Saccharomyces Genome Database
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (855653)
    Homologues
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    UniProt
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    Internet
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