Caenorhabditis elegansGenAge entry for isp-1 (Caenorhabditis elegans)

Gene information (ID: 379)

Symbol
isp-1
Name
Iron-Sulfur Protein
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Iron sulfur protein of mitochondrial complex III

Potential relevance to longevity and/or ageing

Observations
A missense mutation leads to low oxygen consumption, decreased sensitivity to reactive oxygen species, and increased mean (60%) and maximum (100%) lifespan.
% change in max lifespan
Maximum lifespan is 100% higher.
% change in avg or median lifespan
Average lifespan is 60% higher.
Lifespan Effect
Increase
Genetic Manipulation
Mutation
Primary reference
    Observations
    Treating the respiratory mutant isp-1(qm150) with rps-15 or S6K/rsks-1 RNAi further extended its lifespan by 25-30%.
    Lifespan Effect
    Increase
    Genetic Manipulation
    RNA interference
    Longevity Category
    Anti-Longevity
    Primary reference

      In other databases

      GenAge model organism genes
      • A homolog of this gene for Saccharomyces cerevisiae is present as RIP1

      Homologs in other organisms

      Danio rerio
      uqcrfs1
      Drosophila melanogaster
      RFeSP
      Homo sapiens
      UQCRFS1P1
      Mus musculus
      Uqcrfs1
      Rattus norvegicus
      Uqcrfs1
      Saccharomyces cerevisiae
      RIP1
      Schizosaccharomyces pombe
      rip1

      External links

      WormBase
      Search
      Ensembl
      Search
      Entrez Gene
      View on Entrez Gene database (177609)
      Homologues
      Search HomoloGene
      UniProt
      Search
      Internet
      Search Google or Search Google Scholar