Mus musculusGenAge entry for Irs1 (Mus musculus)

Gene information (ID: 377)

Symbol
Irs1
Aliases
G972R; IRS-1
Name
insulin receptor substrate 1
Organism
Mus musculus (AnAge)
Known functions and activities
Cytoplasmic signalling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines

Potential relevance to longevity and/or ageing

Observations
Median lifespan was extended 18% in knockouts from both sexes and 32% in females. Female animals displayed signs of resistance to ageing markers in skin, bone, immune system, and motor dysfunction, in spite of mild, lifelong insulin resistance. Heterozygous animals had normal lifespans.
% change in avg or median lifespan
Median lifespan is 18% higher.
Lifespan Effect
Increase
Genetic Manipulation
Knockout
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as IRS1
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as IRS1

    Homologs in other organisms

    Danio rerio
    irs1
    Homo sapiens
    IRS1
    Rattus norvegicus
    Irs1

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (16367)
    Homologues
    Search HomoloGene
    UniProt
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    Internet
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