Caenorhabditis elegansGenAge entry for ifg-1 (Caenorhabditis elegans)

Gene information (ID: 362)

Symbol
ifg-1
Name
Initiation Factor 4G (eIF4G) family
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
A scaffold protein for translation initiation factors

Potential relevance to longevity and/or ageing

Observations
Post developmental RNAi resulted in a mean and maximum lifespan daf-16 dependent extension.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference
    Observations
    RNAi increased maximum lifespan by about 30%. Reducing the levels of eIF2B or eIF4G did not extend the lifespan of daf-16 mutants at all. eIF2B and eIF4G RNAi slightly shortened the lifespan of daf-2 mutants. sir-2.1 deletion mutant was subjected to sir-2.1(ok434), to RP, S6K, TOR or eIF RNAi; In each case, lifespan was extended.
    % change in max lifespan
    Maximum lifespan is 30% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    RNA interference
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      Inhibition of ifg-1 during adulthood led to a 36% increase in maximum lifespan. Inhibition of at least one eIF4E isoform and two of the three poly(A)-binding proteins also has a significant effect on lifespan extension. Inhibition of let-363 increased lifespan in both the N2 background and when ifg-1 was inhibited. In the daf-2 (e1370) mutant background, inhibition of either ifg-1 or rsks-1 further extended lifespan by 70% and 24%, respectively. Inhibition of either ifg-1 or rsks-1 extended lifespan by 27% and 14%, respectively, in a daf-16 (mu86 ) background. Inhibition of either ifg-1 or rsks-1 in the clk-1(e2519) mutant background led to a further lifespan extension by 19% and 13%, respectively. Inhibition of either ifg-1 or rsks-1 extended lifespan in the eat-2 background by 54% and 11%, respectively. In a sir-2.1 mutant background, ifg-1 inhibition extended lifespan by 93% and rsks-1 inhibition by 33%.
      % change in max lifespan
      Maximum lifespan is 36% higher.
      Lifespan Effect
      Increase
      Genetic Manipulation
      RNA interference
      Longevity Category
      Anti-Longevity
      Primary reference
        Observations
        RNA interference in adulthood resulted in a 55% mean lifespan extension.
        % change in avg or median lifespan
        Average lifespan is 55% higher.
        Lifespan Effect
        Increase
        Genetic Manipulation
        RNA interference
        Longevity Category
        Anti-Longevity
        Primary reference
          Observations
          RNAi resulted in a 30% maximum lifespan extension compared to wild-type.
          % change in max lifespan
          Maximum lifespan is 30% higher.
          Lifespan Effect
          Increase
          Genetic Manipulation
          RNA interference
          Longevity Category
          Anti-Longevity
          Primary reference

            In other databases

            GenAge model organism genes
            • A homolog of this gene for Saccharomyces cerevisiae is present as TIF4631

            Homologs in other organisms

            Danio rerio
            uncharacterized_F1QF
            Drosophila melanogaster
            eIF4G2
            Homo sapiens
            EIF4G1
            Mus musculus
            Eif4g1
            Saccharomyces cerevisiae
            TIF4631
            Schizosaccharomyces pombe
            tif471

            External links

            WormBase
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            Ensembl
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            Entrez Gene
            View on Entrez Gene database (174322)
            Homologues
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            UniProt
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            Internet
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