Saccharomyces cerevisiaeGenAge entry for HSP104 (Saccharomyces cerevisiae)

Gene information (ID: 347)

Symbol
HSP104
Name
chaperone ATPase HSP104
Organism
Saccharomyces cerevisiae (AnAge)
Known functions and activities
Heat shock protein

Potential relevance to longevity and/or ageing

Observations
A 40% reduction in replicative lifespan was observed in knockouts. Overexpression had no effect on replicative lifespan but suppressed the reduced lifespan of Sir2-deficient cells.
% change in avg or median lifespan
Replicative lifespan is 40% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Knockout
Longevity Category
Necessary for fitness
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Schizosaccharomyces pombe is present as SPBC16D10.08c
    GenDR gene manipulations
    • This gene is present as HSP104

    Homologs in other organisms

    Schizosaccharomyces pombe
    hsp104

    External links

    Saccharomyces Genome Database
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (850633)
    Homologues
    Search HomoloGene
    UniProt
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    Internet
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