Caenorhabditis elegansGenAge entry for gst-10 (Caenorhabditis elegans)

Gene information (ID: 328)

Symbol
gst-10
Name
Glutathione S-Transferase
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Conjugation of the lipid peroxidation product 4-hydroxynonenal (4-HNE)

Potential relevance to longevity and/or ageing

Observations
Overexpression resulted in transgenic animals with enhanced stress resistance and increased lifespan by 13-22%.
% change in avg or median lifespan
Lifespan is 13-22% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    RNAi resulted in a decreased maximum lifespan.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    RNA interference
    Longevity Category
    Pro-Longevity
    Primary reference

      In other databases

      GenAge human genes
      • A homolog of this gene for Homo sapiens is present as GSTP1
      LongevityMap
      • A homolog of this gene for Homo sapiens is present as GSTP1

      Homologs in other organisms

      Homo sapiens
      GSTP1
      Mus musculus
      BC021614
      Rattus norvegicus
      RGD1307603

      External links

      WormBase
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (178725)
      Homologues
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      UniProt
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      Internet
      Search Google or Search Google Scholar