Mus musculusGenAge entry for Ghr (Mus musculus)

Gene information (ID: 302)

Symbol
Ghr
Aliases
GHBP; GHR/BP
Name
Growth hormone receptor
Organism
Mus musculus (AnAge)
Known functions and activities
Signal transduction of growth hormone

Potential relevance to longevity and/or ageing

Observations
Knockouts are dwarf with significantly extended lifespan of up to 40% in males in the Ola-BALB/cJ background and 21% in females. In the C57Bl/6J background results are more modest but lifespan is still increased.
% change in avg or median lifespan
Lifespan is 21-40% higher.
Lifespan Effect
Increase
Genetic Manipulation
Knockout
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as GHR
    GenDR gene expression
    • This gene is present as Ghr
    GenDR gene manipulations
    • This gene is present as Ghr
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as GHR

    Homologs in other organisms

    Danio rerio
    ghra
    Homo sapiens
    GHR
    Rattus norvegicus
    Ghr

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (14600)
    Homologues
    Search HomoloGene
    UniProt
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    Internet
    Search Google or Search Google Scholar