Drosophila melanogasterGenAge entry for Gclm (Drosophila melanogaster)

Gene information (ID: 294)

Symbol
Gclm
Aliases
4919; box; CG4919; Dmel\CG4919; DmGCLM; DmGCSl; GCLm; Gcs
Name
Glutamate-cysteine ligase modifier subunit
Organism
Drosophila melanogaster (AnAge)
Known functions and activities
Catalyzes the formation of glutathione

Potential relevance to longevity and/or ageing

Observations
Overexpression extended the mean lifespan by up to 24%.
% change in avg or median lifespan
Average lifespan is up to 24% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as GCLM

    Homologs in other organisms

    Caenorhabditis elegans
    CELE_E01A2.1
    Danio rerio
    gclm
    Homo sapiens
    GCLM
    Mus musculus
    Gclm
    Rattus norvegicus
    Gclm

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (248194)
    Homologues
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    UniProt
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    Internet
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