Caenorhabditis elegansGenAge entry for frh-1 (Caenorhabditis elegans)

Gene information (ID: 287)

Symbol
frh-1
Name
FRataxin (involved in human Friedrich's ataxia) Homolog
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Regulation of mitochondrial iron transport and respiration

Potential relevance to longevity and/or ageing

Observations
While complete knock-out of FRH-1 results in arrested development or short lifespan, partial deficiency (without completely abolishing its expression) extends worm lifespan in a p53 dependent manner. It was however observed that a substantial frataxin suppression (more than 50% compared to wild-type) is required to extend C. elegans lifespan, while lower suppression levels displaying unsignificantly different longevity phenotypes.
% change in max lifespan
Maximum lifespan is aproximately 18% higher.
% change in avg or median lifespan
Median lifespan is aproximately 25% higher.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference
    Observations
    Inactivation by RNA interference resulted in small body size, reduced fertility, altered responses to oxidative stress and life-extension.
    Lifespan Effect
    Increase
    Genetic Manipulation
    RNA interference
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      Upon RNAi lifespan is significantly reduced, and worms have increased sensitivity to oxidative stress.
      Lifespan Effect
      Decrease
      Genetic Manipulation
      RNA interference
      Longevity Category
      Pro-Longevity
      Primary reference

        In other databases

        GenAge model organism genes
        • A homolog of this gene for Mus musculus is present as Fxn
        • A homolog of this gene for Drosophila melanogaster is present as fh
        • A homolog of this gene for Saccharomyces cerevisiae is present as YFH1

        Homologs in other organisms

        Danio rerio
        fxn
        Drosophila melanogaster
        fh
        Mus musculus
        Fxn
        Rattus norvegicus
        Fxn
        Saccharomyces cerevisiae
        YFH1
        Schizosaccharomyces pombe
        SPCC1183.03c

        External links

        WormBase
        Search
        Ensembl
        Search
        Entrez Gene
        View on Entrez Gene database (174002)
        Homologues
        Search HomoloGene
        UniProt
        Search
        Internet
        Search Google or Search Google Scholar