Caenorhabditis elegansGenAge entry for atp-2 (Caenorhabditis elegans)

Gene information (ID: 25)

Symbol
atp-2
Name
ATP synthase F1 subunit gamma
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase

Potential relevance to longevity and/or ageing

Observations
RNA interference of atp-2 results in an increased lifespan.
% change in avg or median lifespan
Mean lifespan is 14.8% higher.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference
    Observations
    atp-2 mutation significantly lengthen (by 20%) the lifespan of the arrested animals.
    % change in avg or median lifespan
    Average lifespan is 20% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Mutation
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      RNA interference results in extended lifespan.
      Lifespan Effect
      Increase
      Genetic Manipulation
      RNA interference
      Longevity Category
      Anti-Longevity
      Primary reference
        Observations
        Post developmental RNAi resulted in a 43% increase in mean lifespan.
        % change in avg or median lifespan
        Average lifespan is 43% higher.
        Lifespan Effect
        Increase
        Genetic Manipulation
        RNA interference
        Longevity Category
        Anti-Longevity
        Primary reference

          In other databases

          GenAge model organism genes
          • A homolog of this gene for Saccharomyces cerevisiae is present as ATP2

          Homologs in other organisms

          Danio rerio
          zgc:163069
          Drosophila melanogaster
          ATPsyn-beta
          Homo sapiens
          ATP5B
          Mus musculus
          Atp5b
          Rattus norvegicus
          Atp5b
          Saccharomyces cerevisiae
          ATP2
          Schizosaccharomyces pombe
          atp2

          External links

          WormBase
          Search
          Ensembl
          Search
          Entrez Gene
          View on Entrez Gene database (175716)
          Homologues
          Search HomoloGene
          UniProt
          Search
          Internet
          Search Google or Search Google Scholar