Mus musculusGenAge entry for Atm (Mus musculus)

Gene information (ID: 24)

Symbol
Atm
Aliases
AI256621; C030026E19Rik
Name
Ataxia telangiectasia mutated homolog (human)
Organism
Mus musculus (AnAge)
Known functions and activities
DNA repair and cell cycle control

Potential relevance to longevity and/or ageing

Observations
Cells show slow growth in culture and premature senescence, telomeres are extensively shortened in multiple tissues of ATM(-/-) mice. There is increased tumor incidence in ATM(-/-) mice.
Lifespan Effect
Not Recorded
Genetic Manipulation
Mutation
Primary reference
    Observations
    Atm-deficient mice are retarded in growth, do not produce mature sperm, and exhibit severe defects in T cell maturation while going on to develop thymomas.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    Deletion
    Longevity Category
    Pro-Longevity
    Primary reference
      Observations
      Mice homozygous for the disrupted Atm allele displayed growth retardation, neurologic dysfunction, male and female infertility secondary to the absence of mature gametes, defects in T lymphocyte maturation, and extreme sensitivity to gamma-irradiation. The majority of animals developed malignant thymic lymphomas between 2 and 4 months of age.
      Lifespan Effect
      Decrease
      Genetic Manipulation
      Deletion
      Longevity Category
      Pro-Longevity
      Primary reference
        Observations
        Mice mutant for Atm and Terc displayed progressive multi-organ system compromise and features of accelerated ageing.
        Lifespan Effect
        Decrease
        Genetic Manipulation
        Mutations
        Longevity Category
        Pro-Longevity
        Primary reference

          In other databases

          GenAge human genes
          • A homolog of this gene for Homo sapiens is present as ATM
          LongevityMap
          • A homolog of this gene for Homo sapiens is present as ATM
          CellAge
          • A homolog of this gene for Homo sapiens is present as ATM

          Homologs in other organisms

          Danio rerio
          atm
          Drosophila melanogaster
          tefu
          Homo sapiens
          ATM
          Rattus norvegicus
          Atm

          External links

          Mouse Genome Informatics
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          Ensembl
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          Entrez Gene
          View on Entrez Gene database (11920)
          Homologues
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          UniProt
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          Internet
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