Caenorhabditis elegansGenAge entry for fmo-2 (Caenorhabditis elegans)

Gene information (ID: 2154)

Symbol
fmo-2
Name
Dimethylaniline monooxygenase [N-oxide-forming]
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Worms overexpressing fmo-2 demonstrated a 20% increase in mean lifespan when compared to the wild type. This pro-longevity effect was dependent on tph-1 in neurons and the serotonin receptor ser-7 in the intestine.
% change in avg or median lifespan
Mean lifespan is 20% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenDR gene manipulations
    • This gene is present as fmo-2

    Homologs in other organisms

    Homo sapiens
    FMO1
    Mus musculus
    Fmo4
    Rattus norvegicus
    Fmo4

    External links

    WormBase
    Search
    Ensembl
    Search
    Entrez Gene
    View on Entrez Gene database (177958)
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar