Drosophila melanogasterGenAge entry for Hex-C (Drosophila melanogaster)

Gene information (ID: 2151)

Symbol
Hex-C
Name
Hexokinase C
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
A mutation that decreased Hex-C activity in flies increased lifespan by more than 6 days. When flies with mutant Hex-C were subjected to dietary restriction no further lifespan extension was displayed, lifespan was comparable to wild type flies under dietary restriction and flies with mutant Hex-C under normal conditions. Thus decreased Hex-C activity triggers a dietary restriction like effect.
Lifespan Effect
Increase
Genetic Manipulation
Mutation
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenDR gene expression
    • A homolog of this gene for Mus musculus is present as Gck
    GenDR gene manipulations
    • This gene is present as Hex-C

    Homologs in other organisms

    Caenorhabditis elegans
    CELE_F14B4.2
    Danio rerio
    gck
    Homo sapiens
    GCK
    Mus musculus
    Gck
    Rattus norvegicus
    LOC100364027
    Schizosaccharomyces pombe
    hxk1

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (44008)
    Homologues
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    UniProt
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    Internet
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