Saccharomyces cerevisiaeGenAge entry for NAT4 (Saccharomyces cerevisiae)

Gene information (ID: 2149)

Symbol
NAT4
Name
Nat4p
Organism
Saccharomyces cerevisiae (AnAge)

Potential relevance to longevity and/or ageing

Observations
Under normal conditions downregulation of NAT4 in yeast increased mean replicative lifespan by 21%. When yeast cells lacking NAT4 were subjected to calorie restriction (0.1% glucose versus 2% glucose) no further lifespan extension was displayed, lifespan was comparable to wild type cells under calorie restriction and yeast cells lacking NAT4 under normal conditions.
% change in avg or median lifespan
Mean replicative lifespan is 21% higher.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenDR gene manipulations
    • This gene is present as NAT4

    Homologs in other organisms

    Schizosaccharomyces pombe
    SPCC825.04c

    External links

    Saccharomyces Genome Database
    Search
    Ensembl
    Search
    Entrez Gene
    View on Entrez Gene database (855091)
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar