Drosophila melanogasterGenAge entry for Ire1 (Drosophila melanogaster)

Gene information (ID: 2148)

Symbol
Ire1
Name
Inositol-requiring enzyme-1
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Whole body depletion of Ire1 using RNA interference reduced the lifespan of flies and negated the lifespan extending effects of dietary restriction. This effect was found to be tissue specific, Ire1 expression in the midgut is required for starvation tolerance and lifespan extension.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as ire-1
    GenDR gene manipulations
    • This gene is present as Ire1
    • A homolog of this gene for Caenorhabditis elegans is present as ire-1
    • A homolog of this gene for Saccharomyces cerevisiae is present as IRE1

    Homologs in other organisms

    Caenorhabditis elegans
    ire-1
    Danio rerio
    ern2
    Homo sapiens
    ERN2
    Mus musculus
    Ern2
    Rattus norvegicus
    Ern2
    Saccharomyces cerevisiae
    IRE1
    Schizosaccharomyces pombe
    ppk4

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (42358)
    Homologues
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    UniProt
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    Internet
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