Mus musculusGenAge entry for G6PD (Mus musculus)

Gene information (ID: 2104)

Symbol
G6PD
Name
glucose-6-phosphate dehydrogenase
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Female mice overexpressing human G6PD (G6PD-Tg) had a 13.7% increase in median lifespan compared to wild type mice. G6PD-Tg mice had lower levels of oxidative stress and increased protection from age-associated functional decline. However, male mice showed no increase in median lifespan and neither male or female mice showed any increase in maximal lifespan.
% change in avg or median lifespan
Median lifespan is 14% higher in females.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Drosophila melanogaster is present as Zw
    • A homolog of this gene for Saccharomyces cerevisiae is present as ZWF1
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as G6PD
    CellAge
    • A homolog of this gene for Homo sapiens is present as G6PD

    Homologs in other organisms

    Homo sapiens
    G6PD
    Homo sapiens
    G6PD
    Homo sapiens
    G6PD
    Homo sapiens
    G6PD
    Homo sapiens
    G6PD
    Homo sapiens
    G6PD
    Homo sapiens
    G6PD

    External links

    Mouse Genome Informatics
    Search
    Ensembl
    Search
    Entrez Gene
    View on Entrez Gene database (2539)
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar