Caenorhabditis elegansGenAge entry for acn-1 (Caenorhabditis elegans)

Gene information (ID: 2101)

Symbol
acn-1
Name
Inactive angiotensin-converting enzyme-related protein
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
When acn-1, a worm homologue of ACE, was downregulated mean lifespan was increased 21% and maximum lifespan increased 18%. Similar results were shown when acn-1 was downregulated from adulthood. In addition, lifespan was increased at higher temperatures, age-related degenerative changes were delayed and stress resistance was increased.
% change in max lifespan
Maximum lifespan is 18% higher.
% change in avg or median lifespan
Mean lifespan is 21% higher.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    ace2
    Drosophila melanogaster
    Acer
    Homo sapiens
    ACE2
    Mus musculus
    Ace3
    Rattus norvegicus
    Ace3

    External links

    WormBase
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    Entrez Gene
    View on Entrez Gene database (180780)
    Homologues
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    UniProt
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    Internet
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