Caenorhabditis elegansGenAge entry for pdp-1 (Caenorhabditis elegans)

Gene information (ID: 2065)

Symbol
pdp-1
Name
Pyruvate Dehydrogenase Phosphatase homolog
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Pdp-1 overexpression increases the lifespan of wild-type and daf-2 worms (by 17%), while pdp-1 mutants live slightly shorter than wild-type animals (by 8%).
% change in avg or median lifespan
Mean lifespan is 17% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as PTC5

    Homologs in other organisms

    Danio rerio
    si:ch211-15p9.2
    Danio rerio
    pdp2
    Danio rerio
    pdp1
    Drosophila melanogaster
    Pdp
    Homo sapiens
    PDP2
    Homo sapiens
    PDP1
    Mus musculus
    Pdp2
    Mus musculus
    Pdp1
    Rattus norvegicus
    Pdp2
    Rattus norvegicus
    Pdp1
    Saccharomyces cerevisiae
    PTC5
    Schizosaccharomyces pombe
    SPAC10F6.17c

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (172035)
    Homologues
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    UniProt
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    Internet
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